Ghana has been a destination for immigration in the post-colonial era and is still today hence the detrimental and potential contributions made by immigrants are worthy of investigation and examination. The country's non-enforced immigration laws have often made it a place for its neighbors to enter and work. Nigeria, a neighbor of Ghana breeds more developmental challenges than Ghana hence the movement of its citizens to Ghana for jobs and other purposes. Preferably, they move to Ghana because of the many cultural similarities and English as the official languages of the two countries. The research employs a mixed-method approach, as the subject cannot be addressed by just using either a qualitative or a quantitative method. The Study analyzes the contribution of Nigerian immigrants with multiple linear regression models and examines the relationship between Labor Market, Public Finance, and Real GDP. The Pearson's correlation coefficient was used to test the correlation between each independent variable and dependent variables. To find out Nigerian immigrant contribution to the economy of Ghana, labor Market, and Public Finance were measured against the dependent variable Real GDP in the multiple linear regression models. The results showed that there was no positive relationship between the independent variables (Labor Market and Public Finance and the dependent variable Real GDP). This implies Nigerian immigrants do not contribute to the Real GDP of Ghana.